DDR-Geschichten

BMI1, ATM and DDR

The polycomb group protein BMI1 is a component of the polycomb repressive complex 1 (PRC1). Although lacking enzymatic activity, BMI1 makes an important contribution to the intrinsic E3 ubiquitin ligase activity of PRC1 via binding of the catalytic subunit RING2. PRC1 catalyzes mono-ubiquitination of histone H2A at lysine 119 (H2AK119Ub), a well-recognized epigenetic marker associated with gene...

Cell-ECM interactions control DDR

Fundamental to an improvement of cancer cure rates is a better understanding of the underlying molecular mechanisms driving resistance to standard treatments such as radioand chemotherapy. A powerful and promising approach to sensitize cancer cells to therapy is represented by Paul Ehrlich ́s old and still up-to-date concept of the “magic bullet”. Reviewing the complexity of the “hallmarks of ca...

Einführung: Die Zuse-Forschung und die Probleme der Pionier-Geschichten

Biographische und monographische Darstellungen zu Konrad Zuse konzentrierten sich in der Vergangenheit sehr stark auf den Nachweis der Priorität der Zuse-Maschinen vor den amerikanischen und englischen Computer-Entwicklungen. Der einführende Beitrag gibt einen Überblick über die Problemstellungen, Ergebnisse und offenen Fragen der bisherigen Forschung über den wichtigsten deutschen Computerpion...

DDR and the Complexity of Contemporary Conflict

A Low Power DDR SDRAM Controller Design

This paper work leads to a working implementation of a Low Power DDR SDRAM Controller that is meant to be used as a reference for future implementations. . The DDR SDRAM is an enhancement to the traditional Synchronous DRAM. It supports data transfers on both edges of each clock cycle, effectively doubling the data throughput of the memory device. In this project Low Power Techniques are propos...